Program

Scheduled Abstracts by Division
Biological and Medicinal Chemistry
Sunday AM
BM1
204
Functional RNAs: From Natural to Synthetic
Organizer(s) - M DeRosa, JP Pezacki
Chair(s) - Maria DeRosa, John Pezacki
08:00
Towards Intracellular Theranostics Using Inorganic Nanoparticles Zhou F, Rolo P, Noor MO, Tavares AJ, Uddayasankar U, Shahmuradyan A, $*Krull UJ
08:40
Synthesis of siRNA Prodrugs: Incorporation and Evaluation of 2'-O-phenylalanine Acetal Esters Bogojeski JJ, Lietard J, Steals E, Yamada K, Damha MJ
09:00
Photoregulation of DNA Functions by Cyclic Azobenzene-tethered Oligonucleotides Eljabu F, Dhruval J, *Yan T
09:20
pH-driven Aptaswitch for the Catch and Release of a Target Protein McConnell EM, Bolzon R, Mezin P, $*DeRosa MC
09:40
Electrochemical Sensing of microRNAs in Blood $*Berezovski MV, Labib M
10:00
 
Coffee Break
10:20
Recent Advances in RNA Chemistry: From RNA Chips to Novel Functional RNA Structures $*Damha MJ, Lietard J, Martinez-Montero S, Sack M, Kretschy N, Yahyaee Anzahaee M, Bogojeski J, Katolik A, Abou Assi H, Moroz E, Martin-Pintado N, Fakhoury J, Leroux JC, Gonzalez C, Somoza M, Habibian M, Malek-Adamian E, O'Reilly D
11:00
La+3- Promotes Aminoacylation of dCpA by AA-AMP Analogues for the Direct Ligation Route to Unnatural Aminoacyl tRNA Probes $*Kluger R, Li Y
11:20
 
End of Session
BM3
213
Protein Evolution and Engineering
Organizer(s) - R Chica, N Tokuriki
Chair(s) - Nobuhiko Tokuriki
08:20
A Combined Computational/Experimental Approach to Increase the Efficiency of Cytochrome P450 Engineering Ebert MCCJC, Ang-Houle A, Lamoureux G, $*Pelletier JN
08:40
Protein Engineering of Nanodimensional Multisubunit Proteins $*Honek JF
09:20
Evolutionary Changes in the Total Set of Peptides Recognized by S100 Proteins $*Harms MJ, Wheeler LC
10:00
 
Coffee Break
10:20
Combinatorial Active-site Variants Confer Sustained Clavulanate Resistance in BlaC b-lactamase from Mycobacterium tuberculosis Egesborg P, Carlettini H, Volpato JP, $*Doucet N
11:00
Efficient Generation of Native-like Bispecific Antibodies via Rational Engineering of the Heavy-light Chain Interface *Corper AL, Urosev D, Tom-Yew S, D'Angelo I, Sanches M, Spreter Von Kreudenstein T, Dixit S
11:20
 
End of Session
BM4
207
Enzymology - joint with OR
Organizer(s) - JW Keillor
Chair(s) - Jeffrey Keillor
09:00
Cholesterol Metabolic Pathways in Mycobacterium Tuberculosis: Opportunities for Tuberculosis Drug Discovery and Diagnosis $*Sampson NS
09:40
Catalase Activity Potentiates Yeast Killing by Antifungal Azoles $*English AM, Martins D
10:00
 
Coffee Break
10:20
Protein Lipid-modification: From Enzymology to Biotechnology Applications Distefano MD
11:00
Phosphorylation of Oxysterol Binding Protein (OSBP) and its Effect on Membrane Binding and Lipid Extraction Madarati H, Mukherjee P, Atkinson J, Ridgway N
11:20
 
End of Session
Sunday PM
BM1
204
Functional RNAs: From Natural to Synthetic
Organizer(s) - M DeRosa, JP Pezacki
Chair(s) - Selena Sagan/John Pezacki
14:00
Synthetic Nucleosides for Recognizing Double Stranded DNA and for Catalyzing Sequence Specific mRNA Cleavage $*Perrin DM, Wang Y, Liu E, Liu W, Largy E
14:20
Heme Activation by DNA: Isoguanine Pentaplexes, but not Quadruplexes, Bind Heme and Enhance its Oxidative Activity Shumayrikh N, Sen D
14:40
An Efficient Catalytic DNA that Cleaves L-RNA $*Li Y, Tram K, Xia J, Gysbers R
15:00
Designing Phosphoramidate-modified Oligonucleotides for Improved Biological Properties Vlaho D, $*Damha MJ
15:20
Dissecting Pathogen RNA-protein Interactomes using FAST-iCLIP Sagan SM, Flynn RA, Martin L, Spitale R, Do B, Zarnegar B, Qu K, Khavari P, Quake S, Sarnow P, Chang HY
15:40
Structural Studies of Mutant p19 Proteins with Increased Affinity for Human microRNA-122 Danielson DC, Schirle NT, MacRae IJ, $*Pezacki JP
16:00
 
Coffee Break
16:20
RNA Binding Proteins - It Is All about Location Holcik M
16:40
MicroRNAs Regulate the Immunometabolic Response to Viral Infection in the Liver Singaravelu R, O'Hara S, Jones DM, Chen R, Srinivasan P, Tyrrell DL, Russell RS, $*Pezacki JP
17:00
MicroRNAs, Mitochondria and Macrophages Rayner KJ
17:20
Design and Functional Validation of a Library of Non-canonical Translation Initiation Elements using Phenotypic Sorting and High-throughput Sequencing $*Wieden HJ, Vigar J, Holmqvist E, Vogel J
17:40
 
End of Session
BM3
213
Protein Evolution and Engineering
Organizer(s) - R Chica, N Tokuriki
Chair(s) - Nicolas Doucet
14:00
Complexities in the Early Steps of Evolution of a New Enzymatic Activity Copley SD
14:40
Increasing the Quantum Yield of Red Fluorescent Proteins Using Rational Design Pandelieva AT, Baran MJ, Davey JA, Tremblay V, Sarvan S, Couture JF, $*Chica RA
15:00
Developing Tandem Dimer Fluorescent Proteins Wiens MD, *Shen Y, $Campbell RE
15:20
Engineering an M13-based Platform to Expand the Nano-scale "Toolbox" Available to Technology, Materials, and Medicine Urquhart T, Daub E, $*Honek JF
15:40
Co-evolutionary Constraints on Recombinant Protein Expression Socha RD, $Tokuriki N
16:00
 
Coffee Break
16:20
"Cis-allostery" and Cryptic Epistasis in the Evolution of Enzyme Energy Landscapes $*Theobald DL
17:00
Modulation of Cell Signalling with Synthetic Proteins Sidhu S
17:40
 
End of Session
BM4
207
Enzymology - joint with OR
Organizer(s) - JW Keillor
Chair(s) - Jeffrey Keillor
14:00
Glycosidases and Transition State Charge Stabilization *Bennet AJ, Adamson C, Britton RA
14:40
Structure and Specificity of a Novel b(1,3)/(1,4)-mixed-linkage Glucanase and its Role in Plant Cell Wall Breakdown McGregor N, Tung J, Shojania S, Okon M, McIntosh LP, Van Petegem F, $*Brumer H
15:00
Lessons from Structure-function Relationships in a Family of Sugar/Cyclitol Dehydrogenases $*Palmer DRJ, Aamudalapalli HB, Bertwistle D, Sanders DAR
15:20
Studies on the Mechanism of PhnZ, a Di-iron Dependent Oxygenase that Cleaves Carbon-phosphorus Bonds Séguin JP, $Zechel DL
15:40
Getting Inside the Switch using Molecular Dynamics Simulations and Rapid Kinetics - How the Structural Dynamics of Elongation Factor Tu Contributes to its Nucleotide-related Properties $*Wieden HJ, Girodat D
16:00
 
Coffee Break
16:20
Inhibition Studies on Cell Shape-determining Proteases and Prenyltransferases Liu Y, Abdelmajid W, Mahmoodi N, Morrison JP, $*Tanner ME
17:00
Novel Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase Hit Optimization Leung CY, Chu W, De Schutter JW, Park J, Berghuis AM, $*Tsantrizos YS
17:20
Increased Inhibition of DAHP Synthase by DAHP Oxime at High pH Guides Inhibitor Design Heimhalt M, *Berti PJ
17:40
 
End of Session
Monday AM
BM2
204
Protein Science and its Therapeutic Applications - joint with OR
Organizer(s) - R Ben, N Voyer
Chair(s) - Robert Ben
08:00
New Approaches in Drug Design: The Design of Multivalent Ligands for the Detection and Treatment of the Disease State $*Hruby VJ
08:40
Besides Fibrillization: Putative Role of the Peptide Fragment 71-82 on the Structural and Assembly Behavior of a-synuclein Bédard L, Lefèvre T, Morin-Michaud E, $*Auger M
09:00
Effects of Anti-tau Antibodies on Tau Protein Biochemistry $*Martic S
09:20
Influence of Length and Charge on the Activity of Alpha-helical Amphipathic Antimicrobial Peptides Gagnon M-C, Strandberg E, Grau-Campistany A, Wadhwani P, Reichert J, Bürck J, Rabanal F, Auger M, Paquin J-F, $*Ulrich AS
09:40
A Doubly Cross-linked Hemoglobin Bis-tetramer as a Blood Substitute Singh S, $Kluger R
10:00
 
Coffee Break
10:20
Strategies for Evolving Biologically Active Protein Structures into Drug-like Molecules Lubell WD
11:00
Towards Small-molecule Non-nucleoside Inhibitors of DNA Methyltransferases $*Gagnon A
11:20
Developing Novel SMAC Mimetics as Peptide-based Small Molecule Inhibitors of IAPs to Induce Apoptosis in Cancer Cells McClymont KS, $*Ben RN, Arel-Dubeau A, Martinoli M
Teva Canada Limited Biological and Medicinal Chemistry Lectureship Award Lecture
11:40
Meeting the Challenge of 18F-Labeling for PET with Organotrifluoroborates: A Physical-organic Chemist's Foray from the Bench to the Bedside of Nuclear Medicine $*Perrin DM
12:20
 
End of Session
BM3
213
Protein Evolution and Engineering
Organizer(s) - R Chica, N Tokuriki
Chair(s) - Roberto Chica
08:20
Determination of Functionally Relevant, Co-evolving Residue Sectors in the Ribonuclease A Family Narayanan C, $*Doucet N
08:40
Evolution of Carbohydrate-active Enzymes in Genomes $*Brumer H
09:20
Discovery of Novel Enzymes from Genomic Databases Mak WSM, Tran ST, Marcheschi RM, Bertolani SB, Thompson JT, Baker DB, Liao JCL, $*Siegel JBS
10:00
 
Coffee Break
10:20
Thermal Adaptation via Multistate Computational Protein Design $*Wilson CJ
11:00
Engineering Homing Endonucleases for Genome-editing Applications $*Edgell DR, McMurrough TA, Gloor GB
11:40
Design and Evolution of New Biocatalysts for Organic Synthesis Turner NJ
12:20
 
End of Session
BM4
207
Enzymology - joint with OR
Organizer(s) - JW Keillor
Chair(s) - Jeffrey Keillor
09:00
Mechanism of Alkane Biosynthesis by Cyanobacterial Aldehyde Deformylating Oxygenase: Simple Substrate; Complicated Enzyme $*Marsh ENG
09:40
Biochemical Characterization of N-acetyl-D-glucosamine Deacetylase (NagA) for the Production of Sialic Acids Analogs in Engineered E. coli *Villegas L, $Boddy C
10:00
 
Coffee Break
10:20
Enzyme Activation from Remote Substrate Binding Interactions $*Richard JP, Amyes TL
11:00
The Role of the Aminopyrimidine Ring in the Hydrolytic Decarboxylation of Mandelylthiamin Howe GW, $*Kluger R
11:20
Substrate Promiscuity Compromises Controlled Radical Chemistry in Adenosylcobalamin-dependent Aminomutases $*Wolthers KR, Makins C, Whitelaw DA, Mu C, Walsby CJ
11:40
Lysine Acetylation a Possible Regulator for Protein Disulfide Isomerase Redox Activity Ali Khan H, Caba C, Fontana K, Dubovan B, $Mutus B
12:00
Constriction of the Ammonia Tunnel Reveals a New Role for GTP in CTP Synthase Catalysis $*Bearne SL, McCluskey GD
12:20
 
End of Session
BM8
210
Designer Biomaterials
Organizer(s) - J Harden
Chair(s) - Lisa Muiznieks
08:00
Targeting Collagen Strands by Peptide Hybridization: From Histology to Tissue Engineering and Theranostics $*Yu SM
08:40
Development of Sequence-responsive DNA Cages for the Selective Release of Oligonucleotide Therapeutics Bujold KE, Fakhoury J, Edwardson TGW, Carneiro KMM, Hsu J, Ifabiyi T, Amrein L, Hamblin GD, Panasci LC, $*Sleiman HF
09:00
Interaction between Single Strands of siRNA and Different Chemical Groups Giraud L, $*Giasson S
09:20
DNA Tile Networks on Supported Lipid Bilayers: Long-range Assembly and Selective Patterning Conway JW, $Sleiman HF, Avakyan N, Hsu J, de Rochambeau D, Barlog M, *Bazzi HS
09:40
"Bio-hybrid" Therapeutics Liu M, Fuhrmann G, Wu C, Johansen P, Leroux J-C, $*Gauthier MA
10:00
 
Coffee Break
10:20
Hybrid Nanomaterials for Tissue Engineering $*Alarcon EI, Vulesevic A, Podrebarac JE, Tavakoli Ghinani I, Suuronen EJ, Ross A, Gagnon LB-P, Taylor PK, Mah T-F
11:00
Dendritic grafting on core-shell c-Fe2O3 MNPs for biomolecules immobilization Mitcova L, Buffeteau T, Le Bourdon G, Gaboyard M, Vellutini L, *Heuzé K
11:20
Theranostic Phage-templated Gold Nano-aggregates *Sokullu E, Berchtikou A, Gauthier MA, $Ozaki T
11:40
Functionalized Nanoparticles for Targeted Therapeutic Delivery to Glioblastoma Arnold AE, $Shoichet MS, Damha MJ, Martinez-Montero S, Malek-Adamian E, Petrecca K, Kent C, MacLaughlin CK, Logie J
12:00
Development of Bile Acid-based Nanoparticles for Biomedical Applications Cunningham A, Le Devedec F, Hildgen P, Leblond J, Banquy X, $*Zhu XX
12:20
 
End of Session
Monday PM
BM2
204
Protein Science and its Therapeutic Applications - joint with OR
Organizer(s) - R Ben, N Voyer
Chair(s) - Normand Voyer
14:00
On Structure-function Relationship in Macrocycles $*Yudin AK
14:40
In silico Analysis of Structure and Function of Aminoglycoside 3',5"-phosphotransferas $*Alisaraie LA
15:00
Incorporation Studies of Crown Ether Peptides in Model Membranes by Synchrotron Radiation-based Oriented Circular Dichroism Spectroscopy Savoie J-D, Otis F, Bürck J, Ulrich AS, $*Voyer N
15:20
Signaling by the FGF Receptors $*Hristova K
16:00
 
Coffee Break
16:20
Characterizing Structure, Orientation and Aggregation of Membrane-active Peptides in Lipid Bilayers by OCD and SRCD *Buerck J, Windisch D, Wadhwani P, $Ulrich AS
17:00
Mechanistic Insights into Amyloid Fibril Formation by Means of Conformationally Restricted Peptides $*Bourgault S
17:20
Studies of Synthetic Membrane Perturbing Peptides Incorporating Crown-ethers by Oriented Circular Dichroism Paquet-Côté P-A, Otis F, Bürck J, Ulrich AS, $*Voyer N
17:40
 
End of Session
BM5
213
Natural Product Biosynthesis
Organizer(s) - C Boddy, DC Stevens
Chair(s) - Christopher Boddy
14:00
Studies on Highly Selective but Multifunctional Oxygenases in Secondary Metabolism $*Vederas JC
14:40
Raising the Dead: Investigating the Effect of the bldA Gene on Cryptic Secondary Metabolite Production in Streptomyces calvus Brewer A, *Zhu X, $Zechel DL
15:00
Polyketide Distribution in Terrestrial Environments *Hill P, $Boddy CN
15:20
Genomes to Natural Products and Back $Magarvey NA, Skinnider M, Dejong C, Rees P, Johnston C
16:00
 
Coffee Break
16:20
Marine Bacteria, Inspirational Halogenating Chemists Moore BS
17:00
Uncovering New Molecules and Biosynthetic Mechanisms from Marine Bacteria $Ross AC
17:20
In vitro Reconstitution of Indolmycin Biosynthesis Reveals the Molecular Basis for Oxazolinone Assembly Du Y-L, Alkhalaf LM, $*Ryan KS
17:40
 
End of Session
BM8
210
Designer Biomaterials
Organizer(s) - J Harden
Chair(s) - James Harden
14:00
Bioengineered Fibrous Proteins for New Polymer Systems $*Kaplan DL
14:40
Tailoring Cell Surfaces with Bioorthogonal Chemistry for 3D Tissue Assembly $*Yousaf MNY
15:00
Assembling Biomimetic Surfaces from Modular Amphiphilic Proteins Wan F, Fischer SE, Bagheri M, al-Rekabi Z, Dick S, $*Harden JL
15:20
Rationally Designed Protein Hydrogels with Tailored Mechanical Properties Kong N, Fang J, Gao X, $*Li H
16:00
 
Coffee Break
16:20
Unraveling the Molecular Contributors to Elastic Mechanical Properties for the Rational Design of Elastomeric Biomaterials *Muiznieks LD, Reichheld SE, $Keeley FW
17:00
Resilin-based Hybrid Materials for Applications in Regenerative Medicine $*Kiick KL
17:40
 
End of Session
BM11
207
Biological and Medicinal Chemistry General Session
Organizer(s) - W Ogilvie
Chair(s) - B Linkletter
14:00
Coarse-grained and All-atom Simulations of Protein Chromatographic Adsorption $*Liang-Shenkelberg J, Fieg G
14:20
Understanding the Effects of THz Radiation on Biomolecules *Greschner AA, Ropagnol X, Ferachou D, Razzari L, Perreault J, Ozaki T, $Gauthier M-A
14:40
Protein Analysis and Comparison Between Domains of Different Cladonia uncialis PKS Genes *Abdel-Hameed M, $Sorensen JL
15:20
Correlating the Quality of Crystallographic Water Networks at the Surface of Protein-ligand Complex with the Thermodynamic Profile of Thermolysin Inhibitors *Nasief NN, $Hangauer D
15:40
Combining Computational, Synthetic and Biophysical Tools in the Development of Covalent Prolyl Oligopeptidase Inhibitors De Cesco S, $Mittermaier A, *Moitessier N
16:00
 
Coffee Break
16:20
Folding and Ion Transport in the Uncoupling Proteins of the Central Nervous System Hoang T, Smith MD, $*Jelokhani-Niaraki M
16:40
Cyclic D,L-a-peptides as Conformational Mimics of Parkinson's Disease-associated Alpha-Synuclein (aSyn) Amyloidosis Chemerovski-Glikman M, Shkop E, Richman M, Chill J, $*Rahimipour S
17:00
Mechanistic Studies on Lipopeptide Antibiotics using Lipopeptide Analogs Bearing Fluorescent Labels Taylor R, Palmer M, *Taylor SD
17:20
Synthesis and In Vivo Disposition of Novel Radiolabeled, Bone-targeting Pro-drugs for the Treatment of Osteoporosis Thévenin M, $*Young RN
17:40
 
End of Session
BM12
Canada Hall 2 & 3
Poster
Organizer(s) - R Ben, C Boddy, R Chica
From 17:40 until 19:30
17:40
Comparison of Affinity Mechanism between Cibacron Blue and Different Albumins $*Liang-Schenkelberg J, Fieg G
17:40
Synthesis, Characterisation and Biological Studies of Some Novel Pyrimidine Derivatives Aremu OS, Koorbanally NA, Singh P, Singh M
17:40
Heterologous Expression in Escherichia Coli of a Cytochrome p450 from the Lichen Cladonia Uncialis Bertrand RL, Abdel-Hameed M, $*Sorensen JL
17:40
Lag Phase Iron Influx: How Pathogens Compete with the Host for Iron $*Bertrand RL
17:40
Development of Novel DNA Aptamers for the Detection of Circulating Tumor Cells Using Terahertz Chemical Microscopy Hassan M, Willmore G, $Ozaki T, *DeRosa C
17:40
Chemical Probe Development at Structural Genomics Consortium in Collaboration with Academic Groups *Santhakumar S, $Edwards A, Brown P, Arrowsmith C
17:40
Investigation around the DNMT Activity of Selected NSC Series Leroy M, Roy-Collinet M, Kabro A, Lachance H, $*Gagnon A
17:40
A-ring Substituted 17-Arylsulfonamides of 17-Aminoestra-1,3,5(10)-trien-3-ol as Highly Potent Reversible Inhibitors of Steroid Sulfatase Mostafa Y, Scott B, $*Taylor SD
17:40
Triphosphorylation of Nucleosides using Activated Trimetaphosphate Mohamady S, $*Taylor SD
17:40
Investigation of M13 Bacteriophage Fibers and Thin Films for Applications in Macroscale Materials Science and Bionanotechnology Kim HSD, *Monahan T, Urquhart T, $Honek J
17:40
Targeting Cathepsin D as an Early Biomarker of Alzheimer's Disease *Suchy M, Snir J, Pasternak SH, $Bartha R, Hudson RHE
17:40
Unusual C7- versus "Normal" 5'-O-Dimethoxytritylation of Pyrrolocytidine Analogs: Synthesis of 5'-O-DMT-Pyrrolocytidines Suitable for DNA Oligomerization *Suchy M, $Hudson RHE
17:40
New PARACEST MRI Contrast Agents Based on the DOTMA Scaffold *Suchy M, Li AX, $Bartha R, Hudson RHE
17:40
Design and Synthesis of New Phenolic Acid Analogues as 5-lipoxygenase Inhibitors $*Touaibia M, Doiron J, Hébèrt M, Cormier M, Levesque NA, Vogels CM, Westcott SA, Boudreau LH, Surette ME
17:40
Effects of Calcium and Lipids on Recoverin, a Neuronal Calcium Sensor (NCS) Protein: Evidences from FTIR and Solid-state NMR Spectroscopy *Potvin-Fournier K, Picard-Lafond A, Marcotte C, Schneider M, Valois-Paillard G, Lefèvre T, Cantin L, Salesse C, $Auger M
17:40
Synthesis of Carbohydrate Nanoparticles and Analogs as Anti-adhesins Against Streptococcus suis Infections Akbariromani E, $*ROY R
17:40
Studies on the Mechanism of Action of Daptomycin using the Intrinsic Fluorescence of Daptomycin Analogs Taylor R, Lohani CR, Palmer M, *Taylor SD
17:40
Total Chemical Synthesis of an Analog of the Lipodepsipeptide Antibiotic A54145D Kralt BK, Lohani CR, Taylor SD
17:40
Investigating the Role of Membrane Lipids in Bacterial Resistance and Human Toxicity to Daptomycin Scott B, *Taylor S, Palmer M
17:40
Design of Photo-labelled Analogues of Ivacaftor to Probe the Binding Site on Mutant CFTR Hamilton CM, Chen G, Hung M, Toutah K, *Bear CE, Viirre RD, $Young RN
17:40
Flavonoids in Selected Wild Edible Tropical African Fruit Muhumuza E, *Muhumuza E
17:40
Co-culture Mimic as a Directed Approach to the Discovery of Bioactive Natural Products Sproule AT, Haltli B, Berrue F, $*Kerr RG
17:40
Synthesis of Biotin-functionalized Guanidine in Order to Identify the Mechanism of Diminishes Tumor Growth by Guanidine Mohebali F, $Schmitzer A
17:40
Enantioselective Organocatalytic Michael-aldol Sequence to the Anticancer Natural Product (+)-trans-Dihydrolycoricidine $*McNulty J, Zepeda-Velazquez C
17:40
Photochromic Conversion and Structural Studies of a Red/Green Cyanobacteriochrome from Synechocystis PCC6803 Xu X-L, Gutt A, $Woolley A, *Gärtner W
17:40
Discovering UV Absorbing Metabolites Produced by Extremophiles Living in Arctic Sea Ice Melt Pools Thomas-Sheppard A, Haltli B, $*Kerr R
17:40
Effect of Short Periods of Heating on the Catalytic Rate and Electrophoretic Mobility of Individual Molecules of b-Galactosidase Crawford J, $*Craig DB
17:40
Synthesis of the Fluorogenic Substrate DDAOg-Glucuronide and its Use in Single Molecule Assays of b-Glucuronidase Henderson A, Craig DB, $*Wood TEH
17:40
Synthesis of Siloxane-containing Phospholipids Frampton MB, $Zelisko PM
17:40
Ion Transport across the Cell Membranes Induced by Binol-functionalized Synthetic Transporters Hébert A, $Schmitzer AR
17:40
The Perilous Journey through Mountains of Kinetic Data: Spectral Deconvolution and Coupled Enzyme Kinetics of NtdC Vetter ND, $*Palmer DRJ
17:40
Towards Novel Anti-osteoporosis Conjugate Drugs *Chen G, Xie HB, $Young RN
17:40
Slow and Fast Dynamics in the Crimean-Congo Hemorrhagic Fever Virus Ovarian Tumour Domain Protease Saran S, Khare B, To V, James T, Mcleish N, Lee M, Mark B, $*O'Neil J
17:40
Towards Target-molecule Triggered Release Using Aptamer Polymer "Tapes" for Smart Fertilizers Tsae PK, Zhang X, $*DeRosa MC
17:40
Novel Pyrenyl Derivative to Probe Polymer Polarity Farhangi S, *Duhamel J
17:40
Synthesis and In Vitro Activity of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 Inhibitors $Forcellini E, Shayhidin E, Boulanger M-C, Mahmut A, Lefevbre C-A, Boutin S, Barbeau X, Lagüe P, Mathieu P, *Paquin J-F
17:40
Development of Crop Exudate Specific Aptamers for use in "Smart Materials" Mastronardi E, McKeague M, Monreal C, $*DeRosa MC
17:40
New Analogs of PGD2 for the Treatment of Bone Diseases Comeau C, Hogan P, Tremblay M-C J, Bonin M-A, Parent J-L, de Brum-Fernandes A, $*Marsault E
17:40
Subunit Directed Acetylation and Phase-directed CUAAC in the Formation of Hemoglobin bis-Tetramers Wang A, $*Kluger RH
17:40
Bone-targeting, Novel Release Mechanism Conjugate for the Treatment of Osteoporosis Xie H, Chen G, $*Young R
17:40
Calcium Channel Imaging Tag for use in Fluoresence Microscopy Kerkovius JK, $Menard F
17:40
The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform Purcell MI, Pan L, $Weaver DF
17:40
Design, Synthesis and Cytocidal Activity of Testosterone Dimers as Prospective Antiandrogens Vesper A-R, Lacroix J, C-Gaudreault R, $*Bérubé G
17:40
Polyarginines Macrocyclic Peptides for Cell Penetration: A Study of Structure-uptake Relationship Traboulsi H, Larkin H, Bonin M-A, Volkov L, Lavoie C L, $*Marsault E
17:40
Synthesis and Growth Inhibition Activity of Novel Substituted Pyrimidine Derivatives Bearing a Sulfamide Group $Lefebvre C-A, Forcellini E, Boutin S, Gaudreault R-C, Lacroix J, Lagüe P, Mathieu P, *Paquin J-F
17:40
Structural Characterization of the 14-3-3/Chibby Complex Involved in Wnt Signaling Killoran RC, *Shilton BH, $Choy WY
17:40
The Application of Oligonucleotide Templated Chemical Reactions to DNA Aptamers Mattice CM, Manthorpe JM, $*DeRosa MC
17:40
Structure-based Design of a Photo-controlled Engrailed DNA Binding Protein Kumar A, Ali AM, $*Woolley GA
17:40
Design, Synthesis, Modification and Characterization of Peptide-based Artificial Ion Channels Otis F, Savoie J-D, Racine-Berthiaume C, *Voyer N
17:40
Optogenetic Control of Endogenous CREB Signaling via a Designed Dominant Negative Reis JM, Ali AM, Xia Y, Asim S, Brechun K, Borisenko V, Mercaldo V, Karanicolas J, $*Woolley GA, Josselyn S
17:40
Discovery of Substrates for a SET Domain Lysine Methyltransferase Predicted by Multistate Computational Protein Design *Davey JA, Lanouette S, Couture JF, $Chica RA
17:40
The Effects of Osmotic Stress on the Kinetics and Small-molecule Inhibition of Alkaline Phosphatase Yavroska O, Carrier C, $*Chik JK
17:40
Identification of Antimicrobial Compounds in Commericial Fermented Radish Kimchi Chaytor JL, Li J, Findlay B, McMullen LM, Smith DE, *Vederas JC
17:40
Effect of Microwave Radiation on Trypsin Activity $*Mazinani S, Delong B, Yan T
17:40
Synthesis and Kinetic Evaluation of Irreversible Inhibitors of Tissue Transglutaminases Akbar A, *Keillor JW, Gundemir S, Johnson GVW
17:40
Studying Maleimide Reactivity Using Monomaleimide Fluorogens Tsao K, *Chen Y, $Keillor J
17:40
Designing Novel, Selective Inhibitors for PTPs to Accelerate Nerve Regeneration Following Spinal Cord Injury *Collins CV, Lewis AM, Audic B, $Gunning PT
17:40
Inhibiting the Individual Enzyme Activities of Starch-digesting Maltase-glucoamylase and Sucrase-isomaltase by a- and b-maltose Extended Ponkoranol Analogues Challa VR, $*Pinto BM
17:40
Synthesis and Use of N-Fmoc-L-Fluoroalanine Carpentier C, Godbout R, Otis F, $*Voyer N
17:40
Development of Nucleic Acid based Lateral Flow Biosensors for the Qualitative Detection of Mycotoxins Goudreau D, *Velu R, $DeRosa MC
17:40
The Influence of Denaturants and pH on Metal Binding and Structure of Anthrax Lethal Factor Lo SY, *Siemann S
17:40
Using a Peptidomimetic Strategy in Targeting the SUMO Activating Enzyme Paiva SL, da Silva SR, $Gunning PT
17:40
Metabolic and Genetic Engineering of Escherichia coli for the Production of Complex Carbohydrates Hassan M, Lundgren B, Clark B, Whitfield D, Schoenhofen IC, $Boddy CN
17:40
Molecular Model Assisted Design and Structure-activity Relationship Studies on Anti-HIV Agents that Affect HIV Alternative Splicing Lin ZS, Chabot B, Cheung PK, $*Grierson D
17:40
Design and Synthesis of Type III Pantothenate Kinase Inhibitors as Potential Antibacterial Agents Guan J, *Auclair K
17:40
Exploring the Functional Landscape of Photoactive Yellow Protein using a Fluorescence-based Reporter Assay Brechun K, Borisenko V, Yin L, Hoffmann S, Arndt K, Kumauchi M, Hoff W, $Woolley GA
17:40
Optimization of Potent Small-molecule Inhibitors of STAT3 Proteins *Park J, Lai PS, Rosa D, Lewis AM, Geletu M, $Gunning PT
17:40
Interactions between the Viral Suppressor of RNA Silencing, P19, and miRNA Powdrill MH, Parekh V, Danielson DC, $*Pezacki JP
17:40
The Development of a Robust Assay for Quantification of Adenylating Enzyme Activity Qureshi HI, Kraskouskaya D, $Gunning PT
17:40
Genomic Identification of Ribosomal Natural Products with PRISM 2.0 Skinnider MA, $*Magarvey NA
17:40
Sinefungin as an Activity-probe for Profiling Eukaryotic Enzymes Lafreniere MA, Sherratt AR, Ning Z, Figeys D, $*Pezacki JP
17:40
Screening Techniques for the Determination of Ochratoxin A Aptamer Dissociation Constants *Smith MR, Hill K, Frost N, $DeRosa MC
17:40
Engineering of D-amino Acid Aminotransferase Mutants with Increased Activity towards Aromatic D-amino Acids Walton CJW, Barber JEB, Mouawad A, Couture JF, $*Chica RA
17:40
Effect of Hydrophobic Mismatch on E. coli GlpG Intramembrane Proteolysis Foo ACY, Harvey BGR, Metz JJ, $*Goto NK
17:40
The Selective Detection of Phosphorylated Proteins with the Use of Pyrene Based, turn on Fluorescent Sensors Soor HS, *Kraskouskaya D, $Gunning PT
17:40
Designing Small Molecule Inhibitors of Protein Tyrosine Phosphatases Lewis AM, Ball D, Collins C, Shouksmith A, $Gunning PT
17:40
Conveniently Estimating kcat/KM Values of Cysteine Proteases for Assessing Substrate-based Imaging Agent Candidates Vigliarolo B, Chowdhury M, Moya I, $Phenix C
17:40
Non-thermal Effect of Microwave on Trypsin $*Mazinani S
17:40
Development of an 18F Analogue of Enterolactone to Monitor Enterolactone Uptake by the Prostate via Positron Emission Tomography Allen KJH, $Krol ES
17:40
Biochemical Activities of Macroalgae Moawad MN, Zaki HR, Ghobrial MGN, Bassiouny AR, Kandeel KM, $*Ata A
17:40
Investigation of the Functional Role of Conformational Changes in the MinE Bacterial Cell Division Protein *Ayed S, McLeod L, $Goto NK
17:40
New Agonists of the Keap1/Nrf2 Pathway, a Potential Solution for Oxidative Stress Telated Diseases Deny L, Traboulsi H, Richter MV, Marsault E, $*Bélanger G
17:40
Targeting Indoleamine-2,3-dioxygenase in Neurodegenerative Diseases Diez Cecilia E, *Kelly B, $Weaver D
17:40
Controlling Kinase Activity with a Photoswitchable Inhibitor Wilson DT, $Branda NR
17:40
Optimization and Characterization of Synthetic Antimicrobial Peptides Poulin N, Simon G, Paquet-Côté P-A, Auger M, $*Voyer N
17:40
Characterizing and Harnessing Polyketide Thioesterases Macrocycle and Macrodiolide Formation Heberlig GW, $*Boddy CN
17:40
Metabolomics Approach to Study the Anti-cancer Activity of Andrographis paniculata in Colon Cancer Ahmadi S, $Shaari K, *Stanslas J
17:40
Novel Fluorogenic Antioxidants for Monitoring the Antioxidant Status in Lipid Membranes Greene LE, $*Cosa G
17:40
Heterologous Expression of Fungal Polyketide Biosynthetic Pathways in Mammalian Cells McSorley FR, Heberlig GW, Alain T, Diallo JS, Smith JC, $*Boddy CN
17:40
Enzyme-catalyzed Resolution of 1-Aryl-2,2-dimethyl-1,3-propanediols Mohapatra PP, Mukherjee C, Youssef D, Jha A
17:40
Structural and Mechanistic Studies of a Novel Eukaroytic b-glycosidase Alteen MG, Oehler V, Wilson I, Gloster TM, $*Vocadlo DJ
17:40
Profiling Kinase Activity during Hepatitis C Virus Replication using a Wortmannin-based Probe Desrochers GF, Sherratt AR, Blais DR, Liu JJ, Nasheri N, Ning Z, Figeys D, Goto NK, *Pezacki JP
17:40
A Novel Fluorogenic Substrate for S-nitrosoglutathione Reductase Sun B, Adekoya I, $*Mutus B
17:40
Characterizing the Thioesterase from 6-deoxyerythronolide B Synthase: Stereoselective Macrolide and Macrodiolide Formation Hari TPA, Caissie AA, $*Boddy CN
17:40
Synthesis of Annulated 1,7-diarylhepta-1,6-diene-3,5-diones as Curcumin Analogs Alharbi SA, Mohapatra PP, $*Jha A
17:40
Development of Applications for Bioconjugation, Mediated by Bacterial Transglutaminases Oteng-Pabi SK, $Keillor JW
17:40
Elucidating the Mechanism of Activity for Historically Significant and Current STAT3 Inhibitors Ball DP, Lewis AM, $Gunning PT
17:40
Long Non-coding RNAs in Hepatitis C Virus Infection *Özcelik D, $Pezacki JP
17:40
Novel Anti-acetylcholinesterase Bioactive Steroidal Alkaloids of Buxus natalensis Moawad MN, Zaki HR, Ghobrial MGN, Gengan RM, $*Ata A
17:40
Thermodynamics and Conformation of Heparin Bound to a Carbon Nanotube Janke JJ, Linhardt RJ, $*Garcia AE
17:40
Oligonucleotides Conjugated to a Dye for Real Time Visualization of DNA during Gel Electrophoresis Khalfaoui F, Dicenso G, Wilds CJ, Perreault J
17:40
4-Chlorobensylamine Amides: Antifungal and Structure-activity Studies $*de Sousa DP, Montes RC, Sarmento HM, Lima EO
17:40
O-2 Chiral Non-participating Groups On Mannose Donors To Test For SN1 like TSs Whitfield D M
17:40
Photolabile Linkers for On Support RNA Synthesis O'Reilly D, *Liétard J, $Damha MJ
17:40
A Potent Non-steroidal Inhibitor of Steroid Sulfatase with a Tetrahydroisoquinoline Nucleus: Chemical Synthesis, Plasmatic Concentration and Antisulfatase Activity in Mice *Poirier D, Ayan D, Maltais R
17:40
Macrocyclic Analogues of Neurotensin 8-13 : Effect of Conformational Restriction on Ligand Binding and Signalling Sousbie M, Besserer-Offroy E, Longpré JM, Sarret P, Leduc R, Marsault E
17:40
Isoform Selective Inhibitors of the STAT5 Protein Rana R, *Cummaraswamy AA, Lewis AM, Wingelhofer B, Geletu M, Morrigl R, $Gunning PT
17:40
Oxidation of DNA by Peroxyl Radicals: Product Analysis and Mechanistic Studies Madugundu GS, Wagner JR
17:40
Accessing the Diversity of Natural Products in Urban Environments: Between Molecular and Informatics *Gosse JT, Hill PB, Zhang L, $Boddy CN
17:40
Identification of hGGPPS Inhibitors Ladopoulou E, Ta V, Park J, Draxler WS, Berghuis A, $*Tsantrizos YS
17:40
The Use of Normal Mode Analysis in Refining of Homology Models Larocque M, Frappier V, $*Najmanovich R
17:40
Design and Synthesis of biscalix[4]arenes as Multivalent Hosts for Biomedical Applications Beatty M, Shaurya A, Daze K, Dubicki K, $Hof F
17:40
mRNA Knockdown Using Nucleic Acid Polymer Conjugates Conway JW, Fakhoury JJ, Edwardson TGW, de Rochambeau D, $Sleiman HF, Barlog M, *Bazzi HS
17:40
Synthesis of Tetradepsipeptide Thioester Substrates to Study Valinomycin Thioesterase Oligiomerization and Macrocyclization Dornan MH, Alonzo D, Reimer J, Schmeing TM, $*Boddy CN
17:40
Optimization of a Protein Labelling Technique for Fluorogenic, X-ray Crystallography and NMR Applications Strmiskova M, Goto NK, $*Keillor JW
17:40
IsoMIF: A Novel Tool for the Detection of Molecular Interaction Field Similarities Chartier M, $*Najmanovich R
17:40
Investigation of the Role of Transmembrane Helix 5 in E. coli GlpG Rhomboid Protease Substrate Gating *Uribe C, Foo AC, $Goto NK
17:40
Investigation of Polyketide Synthase Ketoreductase-methyltransferase Didomains Stevens DC, Wagner DT, $*Keatinge-Clay AT
17:40
Effect of Mechanical Deformation on the Structure of Regenerated Fibroin Films as Revealed by Raman and Infrared Spectroscopy Huot A, *Lefèvre T, Rioux-Dubé J-F, Paquet-Mercier F, Nault A-P, Auger M, $Pézolet M
17:40
Design and Application of Versatile, Fluorescent DNA Nanothermometers Gareau DPG, $Vallée Bélisle AVB
17:40
Structural Impact of Gly52 Mutations in the Catalytic Domain of Diphtheria Toxin: What makes CRM197 a Natural Non-toxic Mutant? Sauvé S, Gingras G, $Aubin Y
Tuesday AM
BM5
213
Natural Product Biosynthesis
Organizer(s) - C Boddy, DC Stevens
Chair(s) - David Cole Stevens
08:00
Genome Sequencing of the Lichen Cladonia uncialis Reveals a Rich Biothetic Potential Piercey-Normore M, Abdel-Hameed M, Bertrand R, $*Sorensen JL
08:20
Eliminating Bottlenecks in Natural Product Discovery: The Role of TTA Codons in the Expression of Biosynthetic Pathways in Streptomyces Zechel DL
08:40
Thioesterase Assays with Synthetic SNAC and ACP-tethered Analogues of Bacillaene $Boddy CN, *Horsman ME
09:00
Reinventing Natural Product Discovery Molohon KJ, Melby KL, Cox CL, Metelev M, Tietz JI, $*Mitchell DA
09:20
Visualizing and Harnessing Polyketide Assembly Lines $*Keatinge-Clay AT, Zheng J, Hughes AJ, Piasecki SK, Bailey CB, Gay DC, Fage CD
10:00
 
Coffee Break
10:20
Building, Optimizing and Diversifying Benzylisoquinoline Alkaloid Synthesis in Yeast Martin VJJ
11:00
Investigations into the Biosynthesis of Novel Jadomycin Scaffolds Martinez-Farina CF, Robertson AW, $Jakeman DL
11:20
 
End of Session
BM6
204
Chemical Probes for Biological Questions - joint with OR
Organizer(s) - C Boddy, JP Pezacki
08:00
Fluorescent Chemosensors for Monitoring the Activity of Methylguanine DNA Methyltransferase Beharry AA, $Kool ET
08:20
Synthesis of a Conjugated Fluorescent BODIPY Analogue of Alpha-tocopherol for Imaging in Live Cells and Tissues Ghelfi M, Ulatowski L, Manor D, $*Atkinson J
08:40
Infrared Imaging at the Cellular Level Using Synchrotrons: C. reinhardtii and C. elegans $*Ellis TH, Goff K, Wilson K, Ramanandraitsiory I, Carvalho C
09:00
Molecular Imaging Probe Chemistries Enabling Personalized Medicine *Shuhendler AJ
09:20
New 18F Radiopharmaceuticals for in vivo Imaging: On the Racetrack of Commercialisation $*Schirrmacher RS
10:00
 
Coffee Break
10:20
The Design of Mechanism-based Inhibitors as Potential Probes for PET Imaging Glucocerebrosidase $*Phenix CP, Adams BT, Esarik A, Chowdhury MA, Nicolli S, Lees SJ
10:40
From Chemoselective Fluorescence Imaging to Controlled Delivery of Cytotoxic Agents Enabled by Activatable Probes Durantini A, Godin R, Greene L, Krumova K, Lincoln R, $*Cosa G
11:20
 
End of Session
BM8
210
Designer Biomaterials
Organizer(s) - J Harden
Chair(s) - Emilio Alarcon
08:00
Biomaterials Enhanced Regeneration of the Human Cornea $*Griffith M, Fagerholm P, Phopase J, Ljunggren M, Buznyk O
08:40
Polymers as Tissue Mimetics $*Stover HDH, Zhao Y, Li J, Chen H
09:00
Working Backwards: Designing Polymers for Biomedical Applications $*Shoichet MS, Pakulska M, Vulic K
09:40
Synthesis of Cinnamoyl and Coumarin Functionalized Polycarbonates Chesterman JP, $*Amsden BG
10:00
 
Coffee Break
10:20
Tunable, Antibacterial Activity of Silicone Polyether Surfactants Khan MF, Zepeda-Velazquez L, $*Brook MA
10:40
Ruthenium-based Self-regenerating Antioxidant Catalysts and Materials $*Tennyson AG
11:00
Metal-free Polymerization of Poly(Trimethylene Carbonate) Chesterman JP, $*Amsden BG
11:20
 
End of Session
BM9
202
Structural Bioinformatics
Organizer(s) - R Najmanovich
Chair(s) - Rafael Najmanovich
09:00
Introduction to the Structural Bioinformatics Symposium $*Najmanovich R
09:20
Predicting Protein-protein Interactions from Primary Sequence Data $*Golshani A
10:00
 
Coffee Break
10:20
Achievements and Challenges in Structural Bioinformatics: A Round Table Discussion $*Najmanovich R, Golshani A, Bourne P, Nussinov R, Thronton J
11:00
 
End of Session
BM11
207
Biological and Medicinal Chemistry General Session
Organizer(s) - W Ogilvie
08:00
Cytotoxicity of GAEL-chlorambucil Hybrids on Cancer Cell Lines: Design, Synthesis and Prospects Idowu T, Samadder P, Arthur G, $*Schweizer F
08:20
Synthesis of Light-responsive Bi-cyclic Peptides and its Application in Phage Display Jafari MR, Cruz Ramirez A, $*Derda R
08:40
Novel Triazole-containing Pantothenate Analogues as Antimetabolites for the Coenzyme A Biosynthetic Pathway Tran E, Hoegl A, Darabi H, Kerdo ESC, Saliba KJ, $*Auclair K
09:00
Design and Synthesis of Novel Antiparasitics Brown CE, DiPucchio R, Jones-Brando L, $McNulty J, Bordon C, Yolken R
09:20
Diazomethane An 18-year Odyssey from Organic Synthesis to the Derivatization and Analysis of Biological Molecules $*Manthorpe JM, Smith JC
09:40
Design and Synthesis of "Dendrimer-like" PEG-lipids and Drug-lipid Conjugates for Applications in Lipid Nanoparticle Drug Delivery Meanwell M, $*Fyles TM
10:00
 
Coffee Break
10:20
The Discovery of a Novel Inhibitory Mechanism for an Ubiquitin-like Activating Enzyme, UBA5 *da Silva SR, Paiva S-L, Bancerz M, Geletu M, Lewis AM, Chen J, Cai Y, Lukkarila JL, Dhe-Paganon S, Li H, $Gunning PT
10:40
Gerumycin: A Plasmid-borne Cyclic Depsipeptide in a Fungus-growing Ant Symbiosis Sit CS, Ruzzini AC, Currie CR, $*Clardy J
11:00
Synthesis of a pH Responsive Polymeric Drug Delivery Tailoring Functionalization for Effective Delivery *Li X, $Malardier-Jugroot C
11:20
 
End of Session
Tuesday PM
BM6
204
Chemical Probes for Biological Questions - joint with OR
Organizer(s) - C Boddy, JP Pezacki
14:00
No-wash Fluorescent Labelling of Intracellular Proteins $*Keillor JW, Chen Y, Strmiskova M, Clouthier CM, Tsao K
14:40
Clickable Photoaffinity Probes to Evaluate the Targets and Off-targets of b-Secretase and c-Secretase Inhibitors and Modulators in Live Cells $*Johnson DS
15:20
One-pot Peptide and Protein Chemoenzymatic Conjugation: Combination of Transamination and Click Chemistry Rachel NM, Lévesque É, Charette AB, $*Pelletier JN
15:40
Bacterial Peptidoglycan Dynamics Assessed by Unnatural D-amino Acids and Strain-promoted Alkyne-nitrone Cycloaddition Sherratt AR, MacKenzie DA, Chigrinova M, $Pezacki JP
16:00
 
Coffee Break
16:20
Towards the Identification of Inhibitor Binding Sites in Tissue Transglutaminase using Photolabile Inhibitors and Tandem MS Analysis Apperley KYP, Kubiniok P, Roy I, Thibault P, $*Keillor JW
16:40
Fluorescence-quenched Substrates for Live Cell Imaging of Human Glucocerebrosidase Activity Yadav AK, Shen DL, Shan X, He X, Kermode AR, $*Vocadlo DJ
17:00
Substrate-based Probes for the Tumour Marker Cathepsin B Moya IA, Chowdhury MA, Wang S, Bhiloca S, Vigliarolo BG, Valliant JF, $*Phenix CP
17:20
Probing Host-virus Interactions Using Activity-based Protein Profiling $*Pezacki JP
17:40
 
End of Session
BM7
213
Medicinal Chemistry: Bench to Bedside - joint with OR
Organizer(s) - R Ben, C Boddy
14:00
Prostaglandins and Bone: Design of Novel Bone-targeting EP4 Receptor Agonist Pro-drugs for Treament of Osteoporosis and to Stimulate Bone Repair Young RN
14:40
Targeting a Protein that Isn't There: Strategies for Selective Control of MTAP-depleted Tumors $*Wulff JE, Friedmann JN, Yan L-H, Ackroyd A
15:00
New Synthetic Methods for the Preparation of Anti-inflammatory Natural Products $*Derksen DJ
15:20
New Drug Therapy for the Treatment of Heart Failure and Cardiac Arrhythmias $*Back TG, Vembaiyan K, Wang A, Smith CD, Malig T, Zhang J, Zhou Q, Xie C, Wu G, Chen SRW
15:40
Peptidomimetic Inhibition of Host-targeted Serine Proteases as a Treatment against Influenza Boudreault PL, Colombo E, Thakur P, Gravel E, Désilets A, Marois I, Cliche D, Cloutier A, Leduc R, Richter M, $*Marsault E
16:00
 
Coffee Break
16:20
Starving Bacteria to Find New Antibiotics $*Brown ED
17:00
How We Get Bacteria to Generate Resistance Inhibitors that Lead to the Bacteria's Own Demise in the Presence of Antibiotics $*Auclair K
17:20
 
End of Session
BM9
202
Structural Bioinformatics
Organizer(s) - R Najmanovich
Chair(s) - Rafael Najmanovich
14:00
Computational Design of Stable Globular Proteins using Backbone Ensembles Approximating the Folded and Unfolded States *Davey JA, Damry AM, Euler CK, Goto NK, $Chica RA
14:20
Big Data Meets Structural Bioinformatics $*Bourne PE
15:00
ENCoM: A Coarse-grained Elastic Network Atom Contact Model Frappier V, $*Najmanovich R
15:20
The Structural Basis for Signaling in Cancer and Inflammation $*Nussinov R
16:00
 
Coffee Break
16:20
Enzyme Evolution and Human Variation *Thornton JM, Furnham N, Holliday GL, Cuesta SM, Rahman SA, de Beer T, Laskowski R
17:00
From Genomes to Small-molecules Integrating Systems and Structural Biology Gaudreault F, Frappier V, Chartier M, Larocque M, Chénard T, Duchêne D, Morency LP, Zylber MI, $*Najmanovich RJ
17:40
 
End of Session
BM11
207
Biological and Medicinal Chemistry General Session
Organizer(s) - W Ogilvie
Chair(s) - Jeff Manthorpe
14:00
Targeting Indoleamine-2,3-dioxygenase in Neurodegenerative Diseases Kelly B, *Diez Cecilia E, $Weaver D
14:20
DNA Quadruplexes as a Scaffold for Self Assembling Organocatalysts $*Linkletter BA, Tweel S, Callaghan R, Mosher-Gallant S
14:40
Novel Biomedical Agents from Medicinally Important Plants $*Ata A
15:00
A Unified Approach to Stereoisomeric Iminocyclitols: Discovery of OGA Inhibitors for Alzheimer's Disease Bergeron-Brlek M, Goodwin-Tindall J, Cekic N, Shan X, Zhu Y, Zandberg W, Eskandari R, Davies G, Vocadlo DJ, $*Britton R
15:20
Inhibition of Lipid Peroxidation by Naphthyridinols and their Derivatives in Liposomes and Mammalian Cell Culture Li B, $Pratt DA
15:40
Synthesis and Evaluation of Macrocyclic Peptides as Inhibitors of Aurora B Kinase Protein-protein Interactions Bouayad-Gervais S, *St-Cyr DJ, Courcelles M, Earnshaw WC, $Tyers MD
16:00
 
Coffee Break
16:20
Novel Synthetic Methodologies for the Preparation of Geometrically Constrained Drugs. Development and Application to Prolyl Oligopeptidase Inhibition Airaghi F, De Cesco S, Rocheleau S, Kurian J, Mariaule G, Moitessier N
16:40
Discovery and Structure-activity Relationship of the Oxadiazole Class of Antibiotics Boudreau MA, Ding D, Spink E, Peng Z, Lastochkin E, Song W, Schroeder VA, Wolter WR, Suckow MA, Chang M, $Mobashery S
17:00
Selective Sirt2 Inhibition by Inhibitor-induced Rearrangement of the Active Site $*Jung MH
17:20
Bed Bug Aggregation Pheromone Finally Identified Holmes M, Gries R, Britton R, Zhai H, Draper J, $*Gries G
17:40
 
End of Session
Wednesday AM
BM6
204
Chemical Probes for Biological Questions - joint with OR
Organizer(s) - C Boddy, JP Pezacki
08:00
Design, Synthesis, and Optimization of Photoprobes for Epigenetic Reader Protein CBX7 *Simhadri C, Li J, Daze K, Gignac M, Milosevich N, Wulff J, $Hof F
08:20
Asymmetric and Regiospecific Synthesis of Isotopically Labelled Analogues of the Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid Shields SWJ, *Buist P, $Manthorpe JM
08:40
Total Chemical Synthesis of Fluorescent Analogs of Cyclic Lipodepsipeptide Antibiotics and their Application as Probes for Mechanism of Action Studies $*Taylor SD, Lohani CR, Taylor R, Muraih JK, Palmer M
09:00
Design and Synthesis of Peptidic Probes for Polycomb Group Proteins Upregulated in Stem Cells and Prostate Cancer Milosevich N, Gignac M, Croft C, Simhadri C, Dev A, Prashar N, Li J, Flemmer R, Daze K, $Hof F
09:20
Recent Advances in Catalomics $Yao SQ
10:00
 
Coffee Break
10:20
A Potent STAT5 Protein Small Molecule Inhibitor Gunning PT
11:00
Peptide-peptide Interactions Related to the Oligomerization of the Amyloid Beta Peptide of Alzheimer's Disease $*Rauk A, Petoyan A, Mehrazma B, Opare SKA
11:20
Epigenetic Chemical Probes for Target Discovery $*Schapira M
11:40
Genetically-encoded Libraries of Chemicallly Post-translational Modified (cPTM) Peptides as Source for Ligand Discovery $*Derda R
12:20
 
End of Session
BM7
213
Medicinal Chemistry: Bench to Bedside - joint with OR
Organizer(s) - R Ben, C Boddy
09:20
Cell Wall as Target for Discovery of Novel Antibiotics $*Mobashery S
10:00
 
Coffee Break
10:20
Campylobacter Jejuni Vaccine: The Next Generation $*Monteiro MA, Jiao Y, Guerry P
11:00
Controlling Ice Growth - Designing New and Improved Cryoprotectants Poisson JS, Briard JG, Harden JL, Turner TR, Acker JP, *Ben RN
11:20
Synthesis and SAR Studies of Small Molecules used to Potentiate Tumor-specific Oncolytic Virus Infection *Dornan MH, Krishnan R, Macklin AM, Chen A, Davis C, El Sayes N, Keillor K, Le P, Moi C, Ou P, Pardin C, Selman M, Bell JC, Smith J, Diallo J-S, $Boddy CN
11:40
Novel Cryoprotectants for Red Blood Cells that Prevent Transient Warming Injury Briard JG, *Ben RN, Poisson JS, Turner TR, Acker JP
Wednesday PM
BM7
213
Medicinal Chemistry: Bench to Bedside - joint with OR
Organizer(s) - R Ben, C Boddy
12:40
 
End of Session
BM10
213
Strategies for Stabilization of Enzymes: Biocatalysts and other Applications
Organizer(s) - S MacQuarrie
Chair(s) - Stephanie MacQuarrie
14:00
Tailoring Ionic Liquid Structures for Enzyme Stabilization $*Zhao H, Baker GA, Cowins JV
14:40
Thermo-stable Colloidal Hydrogels for Enzyme Immobilization $Mastour Tehrani S, Lu, Guerin, Soleimani, *Winnik M
15:00
Vitrification of a Model Adenovirus through Spray Drying for Enhanced Thermostability LeClair D, Cranston ED, Dolovich M, Xing Z, Thompson MR
15:20
 
Coffee Break
15:40
Making DNA-based Synthetic Enzymes for Bacterial Detection $*Li Y
16:20
Massively Parallel Genomic Analysis using Tunable Nanoscale Confinement Michaud F, Berard D, $Leslie S
16:40
Current Trends in Stabilization of Phenylalanine Ammonia Lyase $*D'Cunha GB
17:00
 
End of Session